As a research group, they are broadly interested in the ecological and evolutionary dynamics of populations that experience environmental heterogeneity over various spatial and temporal scales. They seek to understand mechanistically how natural selection works in heterogeneous environments, the context dependency and many constraints on this process, and how this ultimately produces an adaptive response.  Their research combines extensive sampling of natural populations and –omics level characterizations, laboratory-based classical and molecular genetics, and experimentation conducted in both the field and laboratory. Much of their work is centered on testing the functional significance of identified molecular polymorphism: establishing concrete links between allelic variation, physiologically mediated performance, and the differential fitness of genotypes among environments. Currently their work focuses on Drosophila. While Drosophila has long been a model system in biology, it remains underutilized in ecological genetics; very little is known about its natural history, basic ecology, and evolutionary dynamics outside the laboratory.